Chemical Engineering

205 Crawford Hall, 16 Greenhouse Road, Kingston, RI 02881 USA

– 401.874.2655

URI
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Samantha Meenach

Samantha Meenach
  • Assistant Professor of Chemical Engineering/Biomedical & Pharmaceutical Sciences
  • Department of Chemical Engineering
  • Phone: 401.874.4303
  • Fax: 401.874.4689
  • Email: smeenach@mail.uri.edu
  • Mailing Address:
    205 Crawford Hall
    16 Greenhouse Road
    Kingston, RI 02881

    Office: 202 Crawford Hall

Research

Professor Meenach’s research lab focuses on the development and implementation of drug delivery vehicles capable of penetrating physiological barriers. This includes, but is not limited to, penetration into tumors, circumventing the mucus barrier of the lung, and the crossing the blood-brain barrier. This work crosses into many disciplines including engineering, biology, and pharmaceutics with the goal of using particle engineering techniques to rationally design systems that provide superior efficacy in treating a wide variety of diseases.

Professor Meenach also seeks to develop in vitro analytical cell culture techniques that allow for the evaluation of specialized therapeutic devices. This goes beyond the “typical” two-dimensional cell culture usually completed in labs, allowing for a more representative picture of the properties of our materials prior to performing expensive, time-consuming, and potentially unnecessary animal experiments.

Education

University of Kentucky, Ph.D. Chemical Engineering (Biomaterials Focus) May 2010
Awarded “Graduate Certificate in Bioactive Interfaces and Devices” via NSF IGERT Program

University of Kentucky, M.S. Chemical Engineering May 2008

University of Kentucky, B.S. Chemical Engineering May 2005

Publications

S.A. Meenach, R.C. McGarry, K.W. Anderson, J.Z. Hilt, H.M. Mansour. Characterization and Aerosol Dispersion Performance of Spray-Dried Chemotherapeutic PEGylated Phospholipid Particles for Dry Powder Inhalation Delivery in Lung Cancer. Eur J Pharm Sci, 49(4), 699-711, 2013.

S.A. Meenach, J.M. Shapiro, J.Z. Hilt, K.W. Anderson. Characterization of PEG-Iron Oxide Hydrogel Nanocomposites for Dual Hyperthermia and Paclitaxel Delivery. J of Biomat Sci-Poly E, 24(9), 1112-1126, 2013.

S.A. Meenach, F.G. Vogt, K.W. Anderson, J.Z. Hilt, R.C. McGarry, H.M. Mansour. Physicochemical Characterization and Optimization of Organic Solution Advanced Spray-Dried Inhalable DPPC and DPPC:DPPE-PEG Microparticles and Nanoparticles for Targeted Dry Powder Pulmonary Delivery. Intl J Nanomedicine, 8, 275-293, 2013.

S.A. Meenach, Y.J. Kim, K.J. Kauffman, N. Kanthamneni, E.M. Bachelder, K.M. Ainslie. Synthesis, Optimization, and Characterization of Camptothecin-Loaded Acetalated Dextran Porous Microparticles for Pulmonary Delivery. Mol Pharmaceutics, 9(2), 290-298, 2012.

N. Kanthamneni, S. Sharma, S.A. Meenach, B. Billet, J.C. Zhao, E.M. Bachelder, K.M. Ainslie. Enhanced Stability of Horseradish Peroxidase Encapsulated in Acetalated Dextran Microparticles Stored Outside Cold Chain Conditions. Intl J Pharm, 431(1-2), 101-110, 2012.

K. Kauffman, N. Kanthamneni, S.A. Meenach, B. Pierson, E.M. Bachelder, K.M. Ainslie. Optimization of Rapamycin-Loaded Acetalated Dextran Microparticles for Immunosuppression. Intl J Pharm, 422, 356-363, 2012.

S.A. Meenach, C.G. Otu, J.Z. Hilt, K.W. Anderson. Controlled Synergistic Delivery of Paclitaxel and Heat from Poly(β-amino ester)/Iron Oxide-Based Hydrogel Nanocomposites. Intl J Pharm, 427(2), 177-184, 2012.

N.S. Satarkar, S.A. Meenach, K.W. Anderson, J.Z. Hilt. Remote Actuation of Hydrogel Nanocomposites: Heating Analysis, Modeling, and Simulations. AIChE J, 57(4), 852-860, 2011.

S.A. Meenach, K.W. Anderson, J.Z. Hilt. Synthesis and Characterization of Thermoresponsive Poly(ethylene glycol)-Based Hydrogels and Their Magnetic Nanocomposites. J Polym Sci Part A: Polym Chem, 48(15), 3229 – 3235, 2010.

S.A. Meenach, J.Z. Hilt, K.W. Anderson. Poly(ethylene glycol)-Based Magnetic Hydrogel Nanocomposites for Hyperthermia Cancer Therapy. Acta Biomater, 6(3), 1039 – 1046, 2010.

S.A. Meenach, A.A. Anderson, M. Suthar, K.W. Anderson, J.Z. Hilt. Biocompatibility Analysis of Magnetic Hydrogel Nanocomposites Based on Poly(N-Isopropylacrylamide) and Iron Oxide. J Biomed Mater Res Part A, 91A(3), 903-909, 2009.

S.A. Meenach, K.W. Anderson, J.Z. Hilt. Hydrogel Nanocomposites: Biomedical Applications, Biocompatibility and Toxicity Analysis. In Safety of Nanoparticles, Webster, T. J., Ed. Springer: New York, 131-157, 2009.

S.A. Meenach, J. Burdick, A. Kunwar, J. Wang. Metal/Conducting-Polymer Composite Nanowires. Small, 3(2), 239-245, 2006.

Grant Awards

RI-INBRE Pilot Proposal Award, “Tumor-Penetrating Acetalated Dextran Nanoparticles Capable of Tandem Delivery of Radiosensitizing Agents for the Treatment of Lung Cancer,” 2013 - 2014

Burroughs Wellcome Collaborative Research Travel Grant, “In Vitro Analysis of Dry Powder Particles for Pulmonary Delivery,” 2014

Fulbright Award, University Student Category, to complete research project, “Development of Nanoparticles for Dual Drug Delivery for Novel Cancer Therapy,” Johann Wolfgang Goethe-Universität, Germany (declined due to previously accepted postdoctoral offer), 2010

National Science Foundation East Asia and Pacific Summer Institute Fellowship, Awarded from The National Science Foundation to complete research at The University of New South Wales, Australia, 2008

AWARDS AND FELLOWSHIPS

2011 – 2013 National Cancer Institute-Cancer Nanotechnology Center Training Fellowship, University of Kentucky
2012 1st Place, SFB Biomaterials Day Oral Presentation, Lexington, KY
2012 NSF Advance Future Faculty Workshop Awardee, Northeastern University
2012 2nd Place, Postdoctoral Basic Science Cancer Research Poster Session, UK Markey Research Cancer Day
2009 1st Place, Materials Science & Engineering Division Poster Session, AIChE Annual Meeting
2009 3rd Place, Bionanotechnology Graduate Student Award Session, AIChE Annual Meeting
2009 1st Place, SFB Biomaterials Day Oral Presentation, University of Kentucky & Case Western Reserve University, Lexington, KY
2007 – 2010 National Science Foundation Integrative Graduate Education and Research Training Fellowship (NSF-IGERT), University of Kentucky
2006 – 2007 Research Challenge Trust Fund Graduate Student Fellowship, University of Kentucky
2005 – 2006 Ira A. Fulton Graduate Fellowship, Arizona State University

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